Ventolin is an inhaler prescribed to overcome the asthma attacks. It is produced as a means for coping bronchospasm. It can also be used in other respiratory diseases chronic obstructive pulmonary disease or lung edema.
Table of Contents
- Drug class
- How to use Ventolin inhaler?
- How long does it take to work?
- How often can I use it?
- Side effects
- Ventolin and pregnancy
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Ventolin inhaler is a selective β2-adrenergic agonist. It affects the β2-adrenoreceptors of the bronchi, exerting a bronchodilating effect at therapeutic doses. The effect on myocardial β1-adrenoreceptors is minimal or completely absent. Albuterol inhibits the release of mast cells leukotrienes, histamine, prostaglandin, as well as other biologically active substances. It suppresses the reactivity of the bronchi (early and late), magnifies the capacity of the lungs, decreases airways resistance, activates ciliated epithelium function, increases mucociliary clearance, increases mucus secretion, and has an expressed bronchodilatory effect. It also prevents bronchospasm induced by the allergen.
This inhaler is utilized to prevent or relieve bronchospasm. The drug affects the secretion of insulin and glycogenolysis. It also reduces the concentration of potassium in the blood plasma with a hyperglycemic and lipolytic effect. It can cause acidosis. In therapeutic doses, it does not have a negative effect on the cardiovascular system, does not cause an increase in blood pressure. It causes the expansion of the coronary arteries, has a positive chronotropic and inotropic effect.
How to use Ventolin inhaler?
- Using an inhaler at high body temperature is strictly prohibited.
- An inhalation cannot be done earlier than 1.5 hours after a meal.
- After the inhalation, do not go out, do not eat, do not talk within an hour.
- It is strictly forbidden to use oil products in the nebulizer (compressor inhaler) since there is a high probability of particles to enter the lungs, which provokes oil pneumonia. Also, it is impossible to apply infusions of herbs, the device is not created for this, it will become clogged and be broken.
- The general course of treatment with inhalation lasts from 5 to 10 days.
- Prepared, open solutions for inhalation stored in the refrigerator, but not more than within a day. If necessary, warm it up to room temperature and use.
- You should not use it more often than 5-6 times a day. The interval between procedures should be at least 1.5 -2 hours.
- The duration of inhalation is about 20 minutes.
- If the doctor has prescribed several different medications, then it is necessary to observe the correct regimen of inhalations. The first inhalation is with a bronchodilator medication, after 1.5 hours – with a drug that dilutes sputum, and after another 1.5 hours – an antibiotic or antiseptic.
How long does it take to work?
After the use of Ventolin inhaler, the action develops quickly. The onset of the effect is within 5 minutes, the maximum – within 30-90 minutes (75% of the maximum effect, is achieved within 5 minutes), the duration is 4-6 hours.
How often can I use it?
It is not recommended to use the inhaler more often than 4 times a day. The need for frequent use of Ventolin maximum doses or in a sudden increase in dose indicates a worsening course of the disease.
This asthma drug is prescribed only for inhalation. The increased need for the use of beta2-adrenoreceptor agonists may be a sign of bronchial asthma exacerbation. In such a situation, it may be necessary to re-estimate the patient’s treatment regimen with adding a simultaneous glucocorticosteroid therapy. Since overdose can be accompanied by the development of adverse events, the dose or frequency of drug use can be increased only on the doctor’s recommendation. The duration of salbutamol action in most patients is from 4 to 6 hours. Patients may use a spacer if they have difficulty in synchronizing the breath using a metered-dose aerosol inhaler under pressure. In children and infants taking albuterol, it is advisable to use a pediatric spacer device with a face mask.
Immune system disorders
Very rarely: hypersensitivity reactions, including angioedema, urticaria, bronchospasm, hypotension and immune system collapse.
Metabolic and nutritional disorders
Rarely: hypokalemia. Beta2-agonist therapy can lead to clinically significant hypokalemia.
Nervous system disorders
- Often: tremor, headache.
- Very rare: hyperactivity.
- Often: tachycardia.
- Infrequently: palpitation.
- Very rarely: arrhythmias, including atrial fibrillation; supraventricular tachycardia and extrasystole.
Rarely: peripheral vasodilation.
Disorders of the respiratory system, organs of the chest and mediastinum.
Very rarely: paradoxical bronchospasm.
Disorders of the gastrointestinal tract
Infrequently: irritation of the oral mucosa and pharynx.
Disorders of the musculoskeletal and connective tissue
Infrequently: muscular spasms.
As with the use of other agents for inhalation therapy, paradoxical bronchospasm may develop with increased wheezing immediately after drug use. This condition requires immediate treatment using an alternative release form or other fast-acting inhaled bronchodilator. This drug should be immediately withdrawn, the patient’s condition should be assessed, and, if necessary, alternative therapy should be prescribed.
Bronchial asthma treatment lies in:
- relief of bronchial asthma attacks, including acute exacerbation of severe asthma;
- prevention of bronchospasm attacks associated with exposure to an allergen or exercise-induced asthma;
- use as one of the components for long-term maintenance therapy of bronchial asthma.
Ventolin and pregnancy
In pregnancy, the drug is prescribed only when the benefit to the mother outweighs any potential risk to the fetus. There was no strictly controlled clinical study on Ventolin teratogenicity. There are data on the birth of children with polydactyly in those mothers who used Ventolin during pregnancy, however, a clear relationship between the occurrence of polydactylism and drug use has not been established. It is possible to use the drug during pregnancy since the risk of placental hypoxemia for the fetus on the background of uncontrolled bronchial asthma in the mother far exceeds the potential risk from taking the drug. However, it is necessary to use Ventolin with caution, as its administration can cause hyperglycemia and tachycardia in the mother and fetus, as well as poor uterine contraction strength, low blood pressure and pulmonary edema.