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Amoxil (Amoxicillin)

Amoxil is an antibiotic from the group of aminopenicillins, which has a wide spectrum of action. The active ingredient is Amoxicillin trihydrate. The drug has a bactericidal property but is not sensitive to microorganisms that produce penicillinase, and to some others. The composition of the antibiotic makes it resistant to penicillinase, reduces cross-resistance to antimicrobial drugs.


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Amoxil is antibacterial, bactericidal, acid-resistant, broad-spectrum agent from the group of semi-synthetic penicillins. It inhibits transpeptidase, violates the synthesis of peptidoglycan (a component of the cell wall of bacteria) during the period of division and growth, causes lysis of bacteria. The drug is active against aerobic gram-positive bacteria: Staphylococcus, Streptococcus and aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp.

What is it used for?

The antibiotic has is prescribed for the treatment of:

  • respiratory infections;
  • infections of the genitourinary system;
  • infections of the digestive tract;
  • infections of the skin, soft tissues.

How to use it?

Take the drug as prescribed by the doctor. Each tablet is taken orally, regardless of meals, not chewed, swallowed as a whole.

The doctor selects the dosage based on the patient’s health, weight, and type of microorganisms that caused the infection. This minimizes the risk of side effects.

Tell your doctor about all other drugs or vitamins you are taking. Other medicines (like those sold without a prescription, as well as those sold only by prescription), as well as alcohol, can interact with antibiotics. This also applies to nutritional supplements, medicinal herbs and even multivitamins. The effectiveness of the antibiotic can be reduced if the doctor does not have the opportunity to take into account all additional drugs.

Read the instructions for use, which will be enclosed in a package with an antibiotic. It contains important information about how Amoxil works, as well as side effects and possible interactions with other drugs.

Do not take more tablets than prescribed. This will increase the risk of side effects.

Complete the course! Even if you feel better, premature discontinuation of treatment may result in resistance to antibiotics and/or recurrence of symptoms. You may need to undergo repeated antibiotic treatment.


How often to take the drug?

Take 2–3 doses depending on the doctor’s prescription and the specific pathology.

The duration of treatment should be determined by the attending physician, based on the diagnosis and nature of the disease. However, in most cases, it is recommended to take tablets not less than 5-10 days or plus 2 days after the symptoms disappear.


The dosage of the drug depends on the age of the patient and the severity of the condition:

  • Adults and children weighing more than 40 kg should take 250 mg – 500 mg 3 times a day, or 500 mg – 1000 mg 2 times a day. With sinusitis, pneumonia and other serious infections, you should take 500 mg – 1000 mg 3 times a day. The daily dose can be increased to a maximum of 6 g;
  • Children weighing less than 40 kg generally take 40–90 mg/kg/day daily in 3 doses, or 25 mg – 45 mg/kg/day in 2 doses. The maximum daily dose for children is 100 mg/kg body weight.

Side effects

Amoxil can cause allergic reactions: urticaria, angioedema, erythema, conjunctivitis, rhinitis, less often – eosinophilia, pain in the joints, fever, anaphylactic shock. It can also cause diarrhea, vomiting, superinfection, nausea. When used with metronidazole, the antibiotic can cause anorexia, nausea, constipation, vomiting, diarrhea, pseudomembranous colitis, stomatitis, glossitis, painful sensations in the epigastric region, less often – hepatitis, blood formation disorders, interstitial nephritis. The prolonged use of the drug can cause convulsions, dizziness, depression, loss of consciousness, ataxia, periodic neuropathy.


Do not take the drug if you are hypersensitive to penicillins, cephalosporins. Also, the antibiotic is not used for infectious mononucleosis, during pregnancy, breastfeeding, blood formation disorders, lymphocytic leukemia, diseases of the nervous system. If you have a sensitivity to nitroimidazole derivatives, do not mix this drug with metronidazole.

Amoxil in pregnancy

Studies have not revealed teratogenic effects (embryo development disorders). However, the use of the drug by a pregnant woman can increase the risk of necrotizing enterocolitis (inflammation and death of the mucous membrane of the small and large intestine) in newborns. Therefore, you should avoid using Amoxil during pregnancy, especially in the I trimester.

This medicine is excreted in mother’s milk. Accordingly, it can cause diarrhea (liquid, frequent stools) and fungal infections of the mucous membranes in the infant.